While there are many forms of current leakage in semiconductors, one especially nefarious type of leakage happens between power rails or power domains. Finding inter-domain leakage is vitally important for design reliability, especially in mixed power system design, but it is a known weakness of traditional electronic design automation (EDA) tools. Specialized EDA tools are needed to accurately identify and analyze the risk of leakage between power domains. The innovative Insight™ Analyzer tool from Siemens EDA can quickly and accurately identify the risk of leakage between power domains, as well as many other circuit reliability issues, using algorithms that provide superior results compared to both simulation and traditional electrical rule checking (ERC) tools.